MESSENGER-RNA AND CYTOSKELETAL FILAMENTS

Citation
G. Bassell et Rh. Singer, MESSENGER-RNA AND CYTOSKELETAL FILAMENTS, Current opinion in cell biology, 9(1), 1997, pp. 109-115
Citations number
57
Categorie Soggetti
Cell Biology
ISSN journal
09550674
Volume
9
Issue
1
Year of publication
1997
Pages
109 - 115
Database
ISI
SICI code
0955-0674(1997)9:1<109:MACF>2.0.ZU;2-B
Abstract
The localization of some mRNAs to distinct intracellular regions is ac hieved through interactions of the mRNA with cytoskeletal filaments. R NA-cytoskeletal interactions exist that influence the transport, ancho ring and translation of mRNA. Recent analysis of RNA movements in livi ng cells suggests the formation of RNA granules and their active trans port along microtubules. The anchoring and translation of mRNA may be mediated by interactions with orthogonal networks of F-actin and elong ation factor 1 alpha.