The localization of some mRNAs to distinct intracellular regions is ac
hieved through interactions of the mRNA with cytoskeletal filaments. R
NA-cytoskeletal interactions exist that influence the transport, ancho
ring and translation of mRNA. Recent analysis of RNA movements in livi
ng cells suggests the formation of RNA granules and their active trans
port along microtubules. The anchoring and translation of mRNA may be
mediated by interactions with orthogonal networks of F-actin and elong
ation factor 1 alpha.