SERUM FERRITIN LEVELS IN CARRIERS OF BETA-THALASSEMIA TRAIT

Hypochromic and microcytic red cell morphology is the most commonly en countered abnormality in a clinical laboratory. Most of such cases hav e iron deficiency anaemia. However, in Pakistan about 5% of the indivi duals with a hypochromic and microcytic blood picture have the beta-th alassaemia trait. These individuals are more than often in a positive iron balance. However iron deficiency (being common) may be associated with the beta-thalassaemia trait. This study of serum ferritin levels was carried out on 135 confirmed cases of the beta-thalassaemia trait . A ferritin assay was done by a radioimmunoassay technique. The resul ts show that the level of serum ferritin in 100 (74%) cases was within normal limits, in 17 (12.6%) cases it was above the normal range, whe reas in 18 (13.4%) cases the level was lower than normal. The importan ce of serum ferritin estimation in carriers of the beta-thalassaemia t rait is highlighted.