INCREASED BACTERICIDAL ACTIVITY AS DOCUMENTED BY SERUM BACTERICIDAL TITERS FOR A TRIPLE COMBINATION OF CELL-WALL ACTIVE AGENTS AGAINST GENTAMICIN-RESISTANT ENTEROCOCCI

Infections caused by enterococci have become increasingly difficult to treat because these bacteria are becoming increasingly resistant to c ommonly used antibiotics such as ampicillin, gentamicin and vancomycin . A consensus for an optimal therapy of enterococcal infections caused by resistant isolates has not yet been determined. We present a patie nt with prolonged enterococcal sepsis in whom a combination of ampicil lin, vancomycin and imipenem was ultimately sucessfull in suppressing enterococcal bacteremia. The enhanced activity of this triple combinat ion was documented by the results of serial serum bactericidal titers.