MEDITERRANEAN LYMPHOMA TREATED WITH ANTIBIOTICS

We report a case of Mediterranean lymphoma treated with antibiotics, A 74-year-old woman visited the hospital due to abdominal pain. Endosco pic examination showed erosions and ulcerations on duodenal mucosa, Bi opsy specimens histologically revealed massive infiltration of small-s ized lymphocytes and plasma cells in subepithelial mucosa. Immunoperox idase staining showed that the infiltrating cells were positively stai ned with anti-alpha heavy chain, Serum IgA concentration was elevated and immunoelectrophoresis of the serum demonstrated monoclonal protein composed of alpha heavy chain, During the antibiotic treatment her sy mptoms disappeared and serum IgA concentration was normalized, Endosco pic examination also showed healing of the duodenal ulceration, The si milarities between Mediterranean lymphoma and gastric mucosa-associate d lymphoid tissue (MALT) type lymphoma, both of which may be related t o bacterial infection and can be treated with antibiotics, are discuss ed in this report.