FRACTIONAL MOVING BLOOD-VOLUME - ESTIMATION WITH POWER DOPPLER US

PURPOSE: To estimate the fraction of moving blood in tissue with power Doppler ultrasound (US). MATERIALS AND METHODS: Power Doppler US meas urements of moving scatterers in a flow tube were made as a function o f successive dilutions of the perfusate. Measurements were normalized relative to the maximum Doppler power in the center of the flow tube a t the highest concentration and were used to calculate the fractional dilution of the perfusate for each run with each dilution used to repr esent increasing amounts of nonmoving soft tissue in the sample volume . The technique was also applied to two clinical examples. RESULTS: Su ccessive dilutions of the perfusate in the flow experiment showed a mo notonic, linear decrease in the Doppler power as a function of dilutio n. CONCLUSION: The power Doppler US technique has the potential to mor e accurately estimate alterations in blood flow and has the advantage of being a continuous parameter that can be depth normalized.