ACUTE MYELOID-LEUKEMIA - LACK OF PREDICTIVE VALUE OF SEQUENTIAL QUANTITATIVE MR-IMAGING DURING TREATMENT

PURPOSE: To assess the use of magnetic resonance (MR) imaging in monit oring treatment response in patients with acute myeloid leukemia (AML) . MATERIALS AND METHODS: Bulk T1 and T2 were determined with at least four MR imaging examinations (strictly timed) during the first 6 weeks of treatment in 29 patients with AML (age range, 16-75 years; 15 fema le, 14 male). Bulk T1 and T2 in responder (n = 22) and nonresponder (n = 7) patients were compared. RESULTS: Relative to pretreatment bulk T 1 values, bulk T1 had increased a mean of 11% at week 1 and had decrea sed a mean of 7% and 39% at weeks 2 and 6, respectively. Values in non responder patients were not statistically significantly different (+11 %, -14%, -38%). CONCLUSION: MR imaging of lumbar bone marrow in patien ts with AML demonstrated statistically significant changes in bulk T1 during treatment that correlated with changes in cellularity. However, neither the early increase in bulk T1 nor the rate or magnitude of th e subsequent decrease in bulk T1 were indicative of a positive respons e to treatment.