ANTICRYPTOCOCCAL ACTIVITY OF NK CELL-ENRICHED PERIPHERAL-BLOOD LYMPHOCYTES FROM HUMAN IMMUNODEFICIENCY VIRUS-INFECTED SUBJECTS - RESPONSES TO INTERLEUKIN-2, INTERFERON-GAMMA, AND INTERLEUKIN-12
Ca. Horn et Rg. Washburn, ANTICRYPTOCOCCAL ACTIVITY OF NK CELL-ENRICHED PERIPHERAL-BLOOD LYMPHOCYTES FROM HUMAN IMMUNODEFICIENCY VIRUS-INFECTED SUBJECTS - RESPONSES TO INTERLEUKIN-2, INTERFERON-GAMMA, AND INTERLEUKIN-12, The Journal of infectious diseases, 172(4), 1995, pp. 1023-1027
Anticryptococcal activity of highly purified NK cells from patients wi
th either early asymptomatic or late-stage human immunodeficiency viru
s (HIV) infection proved to be markedly impaired; activity was reprodu
cibly restored to normal levels by in vitro addition of exogenous inte
rleukin-12 (IL-12). For these highly purified NK cells, responses to I
L-2 and interferon-gamma (IFN-gamma) among HIV-infected patients were
variable, with only 2 of 8 exhibiting significant responses to IL-2 or
IFN-gamma. In contrast, 11.-2 and IFN-gamma consistently enhanced ant
icryptococcal activity of mixed lymphocyte populations, cells that mor
e closely approximate the network likely to be operational in vivo.