CYTOTOXIC T-LYMPHOCYTE RESPONSES TO A LIPOSOME-ADJUVANTED INFLUENZA-AVIRUS-VACCINE IN THE ELDERLY

Citation
Dc. Powers et al., CYTOTOXIC T-LYMPHOCYTE RESPONSES TO A LIPOSOME-ADJUVANTED INFLUENZA-AVIRUS-VACCINE IN THE ELDERLY, The Journal of infectious diseases, 172(4), 1995, pp. 1103-1107
Citations number
15
Categorie Soggetti
Infectious Diseases
ISSN journal
00221899
Volume
172
Issue
4
Year of publication
1995
Pages
1103 - 1107
Database
ISI
SICI code
0022-1899(1995)172:4<1103:CTRTAL>2.0.ZU;2-3
Abstract
This randomized double-blind study evaluated cytotoxic T lymphocyte (C TL) responses of elderly volunteers after parenteral immunization with either liposome-adjuvanted (n = 23) or control subvirion (n = 26) vac cine containing detergent-split influenza A/Taiwan/1/86 (H1N1) virus, Peripheral blood mononuclear cells obtained 0, 2, and 12 weeks after v accination were stimulated in vitro with influenza A (H1N1) virus-infe cted autologous cells and then assayed for influenza virus-specific cy totoxicity using autologous virus-infected target cells, CTL responses to vaccination exhibited influenza A virus heterosubtypic cross-react ivity and were mediated primarily by CD8(+) effector cells, Anti-influ enza virus CTL activity was enhanced to a significantly greater extent by the liposome vaccine than by the control subvirion vaccine, It rem ains to be established whether the advantage of a liposomal formulatio n in terms of an improved CTL response is relevant to vaccine protecti ve efficacy,