Dc. Powers et al., CYTOTOXIC T-LYMPHOCYTE RESPONSES TO A LIPOSOME-ADJUVANTED INFLUENZA-AVIRUS-VACCINE IN THE ELDERLY, The Journal of infectious diseases, 172(4), 1995, pp. 1103-1107
This randomized double-blind study evaluated cytotoxic T lymphocyte (C
TL) responses of elderly volunteers after parenteral immunization with
either liposome-adjuvanted (n = 23) or control subvirion (n = 26) vac
cine containing detergent-split influenza A/Taiwan/1/86 (H1N1) virus,
Peripheral blood mononuclear cells obtained 0, 2, and 12 weeks after v
accination were stimulated in vitro with influenza A (H1N1) virus-infe
cted autologous cells and then assayed for influenza virus-specific cy
totoxicity using autologous virus-infected target cells, CTL responses
to vaccination exhibited influenza A virus heterosubtypic cross-react
ivity and were mediated primarily by CD8(+) effector cells, Anti-influ
enza virus CTL activity was enhanced to a significantly greater extent
by the liposome vaccine than by the control subvirion vaccine, It rem
ains to be established whether the advantage of a liposomal formulatio
n in terms of an improved CTL response is relevant to vaccine protecti
ve efficacy,