Seroprevalence of antibodies to Helicobacter pylori is generally highe
r in developing than in developed countries. The route of transmission
of H. pylori is unknown but is most commonly assumed to be fecal-oral
. Gastroenteritis in a person traveling to developing countries is oft
en a marker of exposure to fecally contaminated food or water, Of 133
initially seronegative young Swedes traveling to developing countries
for a total of 16.4 years, of whom 102 reported having had at least on
e episode of gastroenteritis, not one seroconverted. This rate is lowe
r than in studies of residents in developed countries and casts some d
oubt on the theory of fecal-oral transmission via a common source as a
n important mode of transmission of infection with Helicobacter pylori
.