Mcef. Wijffels et al., ATRIAL-FIBRILLATION BEGETS ATRIAL-FIBRILLATION - A STUDY IN AWAKE CHRONICALLY INSTRUMENTED GOATS, Circulation, 92(7), 1995, pp. 1954-1968
Background In this study we tested the hypothesis that atrial fibrilla
tion (AF) causes electrophysiological changes of the atrial myocardium
which might explain the progressive nature of the arrhythmia. Methods
and Results Twelve goats were chronically instrumented with multiple
electrodes sutured to the epicardium of both atria. Two to 3 Weeks aft
er implantation, the animals were connected to a fibrillation pacemake
r which artificially maintained AF. Whereas during control episodes of
AF were short lasting (6+/-3 seconds), artificial maintenance of AF r
esulted in a progressive increase in the duration of AF to become sust
ained (>24 hours) after 7.1+/-4.8 days (10 of 11 goats). During the fi
rst 24 hours of AF the median fibrillation interval shortened from 145
+/-18 to 108+/-8 ms and the inducibility of AF by a single premature s
timulus increased from 24% to 76%. The atrial effective refractory per
iod (AERP) shortened from 146+/-19 to 95+/-20 ms (-35%) (S1S1, 400 ms)
. At high pacing rates the shortening was less (-12%), pointing to a r
eversion of the normal adaptation of the AERP to heart rate. In 5 goat
s, after 2 to 4 weeks of AF, sinus rhythm was restored and all electro
physiological changes were found to be reversible within 1 week. Concl
usions Artificial maintenance of AF leads to a marked shortening of AE
RP, a reversion of its physiological rate adaptation, and an increase
in rate, inducibility and stability of AF. All these changes were comp
letely reversible within 1 week of sinus rhythm.