Pseudomembranous colitis (PMC) is an inflammatory disorder usually lim
ited to the large intestine and is the consequence of antibiotic assoc
iated Clostridium difficile overgrowth with production of its toxin. i
t has a characteristic gross and microscopic appearance. PMC-like chan
ges, usually associated with hypotension and with operative extensive
gastrointestinal tract involvement, have also been described. In neith
er clinical setting has pseudomembranous appendicitis been recorded. A
case of pseudomembranous appendicitis in a 76 year old woman is descr
ibed.