HUMAN ANTIRABIES VACCINE FROM PASTEUR TO THE PRESENT

Since the first immunization of man against rabies in 1885 by Louis Pa steur, antirabies vaccine has been continuously improved. Treatment fa ilures, clinical infections by the fixed virus, neuroparalytic acciden ts in connection with myelin were progressively eliminated. Vaccines c an be standardized and accurately controlled. After the original spina l cord, adult or newborn animals brains, embryonated eggs, primary tis sue cultures, diploid and permanent cell lines have been used for the vaccine production. Today, safe and potent vaccines are available. New products might be developed from the technology of genetic recombinan ts.