THE ELEVATED PLUS-MAZE IS NOT SENSITIVE TO THE EFFECT OF STRESSOR CONTROLLABILITY IN RATS

Citation
Re. Grahn et al., THE ELEVATED PLUS-MAZE IS NOT SENSITIVE TO THE EFFECT OF STRESSOR CONTROLLABILITY IN RATS, Pharmacology, biochemistry and behavior, 52(3), 1995, pp. 565-570
Citations number
34
Categorie Soggetti
Pharmacology & Pharmacy","Pharmacology & Pharmacy
ISSN journal
00913057
Volume
52
Issue
3
Year of publication
1995
Pages
565 - 570
Database
ISI
SICI code
0091-3057(1995)52:3<565:TEPINS>2.0.ZU;2-Z
Abstract
The present experiments examined the sensitivity of the elevated plus- maze to the effects of stressor controllability. Previous work had est ablished that inescapable but not an equal amount of escapable electri c tail shock reduced social interaction. The present experiments demon strate that prior exposure to shock alters elevated plus-maze behavior , but that this effect is not sensitive to the escapability of the sho ck. These experiments include a replication of the usual pharmacologic effects of benzodiazepine ligands (2 mg/kg diazepam; 0.4 mg/kg methyl ,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) to demonstrate the sensitivity of the elevated plus-maze procedures used. The results pr ovide additional support for the idea that the social interaction and elevated plus-maze measures of ''anxiety'' are sensitive to different processes.