Re. Grahn et al., THE ELEVATED PLUS-MAZE IS NOT SENSITIVE TO THE EFFECT OF STRESSOR CONTROLLABILITY IN RATS, Pharmacology, biochemistry and behavior, 52(3), 1995, pp. 565-570
The present experiments examined the sensitivity of the elevated plus-
maze to the effects of stressor controllability. Previous work had est
ablished that inescapable but not an equal amount of escapable electri
c tail shock reduced social interaction. The present experiments demon
strate that prior exposure to shock alters elevated plus-maze behavior
, but that this effect is not sensitive to the escapability of the sho
ck. These experiments include a replication of the usual pharmacologic
effects of benzodiazepine ligands (2 mg/kg diazepam; 0.4 mg/kg methyl
,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) to demonstrate the
sensitivity of the elevated plus-maze procedures used. The results pr
ovide additional support for the idea that the social interaction and
elevated plus-maze measures of ''anxiety'' are sensitive to different
processes.