AN ATTEMPT TO ATTENUATE EXPERIMENTAL PAIN IN HUMANS BY DEXTROMETHORPHAN, AN NMDA RECEPTOR ANTAGONIST

Authors
KAUPPILA T GRONROOS M PERTOVAARA A
Citation
T. Kauppila et al., AN ATTEMPT TO ATTENUATE EXPERIMENTAL PAIN IN HUMANS BY DEXTROMETHORPHAN, AN NMDA RECEPTOR ANTAGONIST, Pharmacology, biochemistry and behavior, 52(3), 1995, pp. 641-644
Citations number
33
Categorie Soggetti
Pharmacology & Pharmacy","Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
52
Issue
3
Year of publication
1995
Pages
641 - 644
Database
ISI
SICI code
0091-3057(1995)52:3<641:AATAEP>2.0.ZU;2-2
Abstract
Dextromethorphan (100 mg, orally), an NMDA receptor antagonist, did no t significantly attenuate pain intensity or unpleasantness induced by experimental ischemia or by topical capsaicin in healthy human subject s, nor did it increase the threshold for heat pain or mechanical pain. A dose of 200 mg produced marked side effects. Thus, systemically adm inistered dextromethorphan does not attenuate pain at clinically appli cable doses in humans.