The carbenicillin extraction by the 6-amonopenicillanic acid acylation
with phenyl-malonic acid monochloride, in various solvents or mixture
s of organic solvents was studied in order to find out the extraction
variant resulting in the antibiotic high purification. The carbenicill
in extraction in 9:1 dichloromethane - butanol mixture was considered
the optimum one. This extraction variant allows for a high purity anti
biotic production, as per the international pharmacopoeiae.