A STUDY ON CARBENICILLIN PURIFICATION BY LIQUID-LIQUID-EXTRACTION

Authors
VLASE C DIACONU E OSTAPOVICI E TURCULET A MOISUC L BULGARU L
Citation
C. Vlase et al., A STUDY ON CARBENICILLIN PURIFICATION BY LIQUID-LIQUID-EXTRACTION, Revista de chimie, 46(8), 1995, pp. 722-724
Citations number
5
Categorie Soggetti
Chemistry
Journal title
Revista de chimie → ACNP
ISSN journal
00347752
Volume
46
Issue
8
Year of publication
1995
Pages
722 - 724
Database
ISI
SICI code
0034-7752(1995)46:8<722:ASOCPB>2.0.ZU;2-X
Abstract
The carbenicillin extraction by the 6-amonopenicillanic acid acylation with phenyl-malonic acid monochloride, in various solvents or mixture s of organic solvents was studied in order to find out the extraction variant resulting in the antibiotic high purification. The carbenicill in extraction in 9:1 dichloromethane - butanol mixture was considered the optimum one. This extraction variant allows for a high purity anti biotic production, as per the international pharmacopoeiae.