ANTIULCER ACTIVITY OF PENTACAINE AND SOME OF ITS DERIVATIVES - EFFECTON EXPERIMENTALLY-INDUCED GASTRIC AND DUODENAL LESIONS AND ON GASTRIC-ACID SECRETION IN RATS

The antiulcer gastroprotective, and antisecretory effects of selected carbanilates were tested in rats. The compounds K-1905 and K-2002 were found to have be effect effects similar to those of pentacaine in phe nylbutazone- and ethanol-induced gastric injury and in cysteamine-indu ced duodenal lesions; their antisecretory activity was also comparable to pentacaine in pylorus-ligated rats. Compounds P2 and P3 were gener ally less effective than pentacaine, and compound P1 was gaxtrotoxic. Thus pentyloxy-substitution on the benzene ring of the parellel struct ure (K-1905 and K-2002) is more suitable for antiulcer and gastroprote ctive activity than methoxy-substitution on the meta-position (P3) or alkyloxy-substitution on the para-position (P2, PI). The results indic ate that the two carbanilates K-1905 and K-2002 can be considered pros pective antiulcer drugs.