Objective: To determine whether amnioinfusion is associated with labor
and delivery complications, and whether complication type and reporte
d incidence are related to infusion method. Methods: Questionnaires re
garding amnioinfusion experience were sent to every academic obstetric
s and gynecology department in the United States (78 maternal-fetal me
dicine fellowship directors or, if the department did not have a fello
wship, 206 residency directors). A literature review on amnioinfusion
was also performed. Results: Seventy-six percent of fellowship directo
rs and 62% of residency directors responded to our survey, representin
g 644,910 deliveries per year and at least 22,833 amnioinfusions per y
ear. A wide variety of infusion protocols were reported. Forty-nine ce
nters reported at least one associated complication; none was signific
antly associated with any of the various aspects of the many protocols
(P > .05). The mean number (+/- standard error of the mean) of amnioi
nfusions performed annually was similar between centers that did (261
+/- 48) and did not (154 +/- 29) report complications (P = .06). The l
iterature review suggested that amnioinfusion is efficacious and relat
ively safe. Conclusion: Amnioinfusion is performed nationwide accordin
g to widely varying protocols with few associated complications. Neith
er the method employed nor the number of infusions performed appears t
o significantly increase the risk of having a complication.