MODELING AND SIMULATION OF CONTINUOUS ROTATING ANNULAR ION-EXCHANGE CHROMATOGRAPHY FOR SEPARATION OF AMINO-ACIDS

Separation of an amino acid mixture using continuous rotating annular ion-exchange chromatography is numerically simulated by a newly constr ucted mathematical model. Dissociation reactions of amino acids and el uent buffer components, Nernst-Planck-type intraparticle ionic transpo rt, and a nonlinear ion-exchange equilibrium based on ion-exchange sel ectivity are considered in the model. The simulated and the experiment al results agree well under various operation conditions. The effects of rotation speed of the annular bed and the interstitial liquid veloc ity on separation are studied experimentally and theoretically.