F. Rius et al., AGE AS A DETERMINANT OF GLOMERULAR-FILTRATION RATE IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS, Nephrology, dialysis, transplantation, 10(9), 1995, pp. 1644-1647
Background. The level of glomerular filtration rate (GFR) and its dete
rminants in non-insulin-dependent diabetes mellitus (NIDDM) are curren
tly controversial. Design of the study. We measured GFR and effective
renal plasma flow (ERPF) in 121 consecutive NIDDM without evidence of
overt diabetic nephropathy. Age varied from 28 to 70 years, 61.2% were
women and known duration of NIDDM was 0 - 37 years. Hypertension was
detected in 36.4% of patients and 47.8% had microalbuminuria. Results.
An inverse correlation was found between GFR and age, but not with kn
own duration of NIDDM. It was a weak correlation (r = -0.41) but stati
stically significant (P < 0.001). The other variables considered were
not significant by multiple stepwise regression analysis, but patients
with lower GFR tended to have diabetic retinopathy more frequently. G
FR was lower in hypertensive compared to normotensive patients (123 +/
- 28.4 versus 136 +/- 32.5 ml/min/1.73 m(2); P < 0.05), but was not di
fferent between patients with normal and elevated albumin excretion ra
te. ERPF also had an inverse correlation with age (r = -0.45, P < 0.00
1). Conclusion. We conclude that (i) age should be considered as a con
founding variable when evaluating GFR in patients with NIDDM, and (ii)
the age-dependent decline in GFR may mask hyperfiltration in the earl
y stages of diabetic nephropathy in NIDDM.