B. Gilmartin, THE ETIOLOGY OF PRESBYOPIA - A SUMMARY OF THE ROLE OF LENTICULAR AND EXTRALENTICULAR STRUCTURES, Ophthalmic & physiological optics, 15(5), 1995, pp. 431-437
Presbyopia is a condition of age rather than ageing and, as such, is d
evolved from the lamentable situation where the normal age-related red
uction in amplitude of accommodation reaches a point when the clarity
of vision at near cannot be sustained for long enough to satisfy an in
dividual's requirements. Most of our facility to accommodate has been
lost by 55 years-of-age and subsequent deterioration in visual perform
ance at near is attributable to characteristics of senescent vision fa
miliar to the optometrist. Our understanding of the cause of presbyopi
a has then to be derived principally from our understanding of the mec
hanism of accommodation in young eyes. Hermann von Helmholtz did much
to clarify these mechanisms, but despite much research in the 100 year
s since his death, there is still no consensus on their precise nature
. This paper presents a summary of issues, past and present, which hav
e figured in the literature on the physiology of accommodation and pre
sbyopia, and confirms that the pathophysiology of presbyopia is likely
to result from deterioration in structure and function of a number of
inter-related tissues. Changes in crystalline lens dimensions with ag
e, the associated change in geometry of zonular attachments, and chang
es in viscoelastic properties of the lens capsule and lens matrix woul
d, however, appear to be the principal correlates for the onset of pre
sbyopia. Recent models of the biomechanics of accommodation have drawn
attention to the feasibility of extralenticular contributions to pres
byopia and have examined properties of the elasticity and leverage pro
vided by posterior, anterior and tensile fibre systems. The stimulus f
or innovation in the correction and remediation of presbyopia is stron
g as at least 98% of individuals from the industrialised nations will
survive until 45 years-of-age; it is salutary to note that the surviva
l rate 100 years ago was only 60%.