C. Shustik et al., A SOLITARY PLASMACYTOMA OF DONOR ORIGIN ARISING 14 YEARS AFTER KIDNEYALLOTRANSPLANTATION, British Journal of Haematology, 91(1), 1995, pp. 167-168
Allotransplantation of solid organs transfers passenger leucocytes whi
ch may give rise to a state of persistent microchimaerism. In this rep
ort we describe the case of a patient who developed a solitary plasmac
ytoma in a transplanted kidney more than 10 years after allografting,
The diagnosis was established on the basis of the presence of a monocl
onal IgG kappa peak in the serum, and light chain proteinuria, the pla
smacytoid features of tumour cells including cell surface expression o
f IgG, kappa light chains, CD20, CD38 and CD56, the absence of lytic b
one lesions and a normal bone marrow biopsy, and the disappearance of
the monoclonal IgG peak after graft nephrectomy. A donor origin of the
tumour was established by HLA DNA typing of tumour, tumour-free kidne
y tissue, and peripheral blood leucocytes, respectively.