A SOLITARY PLASMACYTOMA OF DONOR ORIGIN ARISING 14 YEARS AFTER KIDNEYALLOTRANSPLANTATION

Allotransplantation of solid organs transfers passenger leucocytes whi ch may give rise to a state of persistent microchimaerism. In this rep ort we describe the case of a patient who developed a solitary plasmac ytoma in a transplanted kidney more than 10 years after allografting, The diagnosis was established on the basis of the presence of a monocl onal IgG kappa peak in the serum, and light chain proteinuria, the pla smacytoid features of tumour cells including cell surface expression o f IgG, kappa light chains, CD20, CD38 and CD56, the absence of lytic b one lesions and a normal bone marrow biopsy, and the disappearance of the monoclonal IgG peak after graft nephrectomy. A donor origin of the tumour was established by HLA DNA typing of tumour, tumour-free kidne y tissue, and peripheral blood leucocytes, respectively.