PRENATAL ETHANOL EXPOSURE IN RATS - LONG-LASTING EFFECTS ON LEARNING

Pregnant Sprague-Dawley rats were fed a liquid diet containing either 0% (group C), 18% (group L), or 36% (group H) ethanol-derived calories (EDC) from gestational day 1 to 20. Male offspring were assessed unde r a conditioned taste aversion paradigm (PND 35-45), in a complex maze (PND 68-80), and for operant behavior (temporal response differentiat ion and motivation to work for food, PND 140-198). Although conditione d taste aversion was fully acquired by all groups, retention of the co nditioned taste aversion response was impaired in group H animals. Imp ortantly, deficits in the acquisition of timing behavior were found in group H (group L not tested), confirming that this operant task is qu ite sensitive in detecting prenatal drug effects and demonstrating tha t neurological effects of prenatal ethanol exposure persist into late adulthood.