The importance of non-local symmetries of differential equations lies
in their manifestation as Lie point symmetries of the equations result
ing from reduction of order. The reason for the determination of these
symmetries in second-order equations with only one Lie point symmetry
is self-evident. However, the disadvantage of non-local symmetries is
that no systematic approach to their determination exists. We present
such an approach (applicable to differential equations of any order)
and apply it to some second-order ordinary differential equations and
show that they have a rich occurrence. We also look at possible genera
lizations of the concept of non-local symmetries.