A REINVESTIGATION OF THE SYNTHESIS OF [N-15(2)]HYDROXYMETHYLIMIDAZOLE- USEFUL IN AN IMPROVED SYNTHESIS OF (D,L)-[TAU,PI-N-15(2)]HISTIDINE

Authors
SILKS LA DUNKLE E UNKEFER CJ SUDMEIER JL BUTLER M BACHOVCHIN WW
Citation
La. Silks et al., A REINVESTIGATION OF THE SYNTHESIS OF [N-15(2)]HYDROXYMETHYLIMIDAZOLE- USEFUL IN AN IMPROVED SYNTHESIS OF (D,L)-[TAU,PI-N-15(2)]HISTIDINE, Journal of labelled compounds & radiopharmaceuticals, 36(10), 1995, pp. 947-951
Citations number
12
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
36
Issue
10
Year of publication
1995
Pages
947 - 951
Database
ISI
SICI code
0362-4803(1995)36:10<947:AROTSO>2.0.ZU;2-E
Abstract
We have reinvestigated the synthesis of [N-15(2)]hydroxymethyl imidazo le from dihydroxyacetone, formaldehyde, and labelled ammonia in an att empt to optimize the yield from the isotope. Conversion of the hydroxy methyl imidazole to histidine was accomplished in good yield without t he need for picric acid as an ion pairing agent.