La. Silks et al., A REINVESTIGATION OF THE SYNTHESIS OF [N-15(2)]HYDROXYMETHYLIMIDAZOLE- USEFUL IN AN IMPROVED SYNTHESIS OF (D,L)-[TAU,PI-N-15(2)]HISTIDINE, Journal of labelled compounds & radiopharmaceuticals, 36(10), 1995, pp. 947-951
Citations number
12
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
We have reinvestigated the synthesis of [N-15(2)]hydroxymethyl imidazo
le from dihydroxyacetone, formaldehyde, and labelled ammonia in an att
empt to optimize the yield from the isotope. Conversion of the hydroxy
methyl imidazole to histidine was accomplished in good yield without t
he need for picric acid as an ion pairing agent.