SENSITIVITY OF STAPHYLOCOCCUS-AUREUS, ISOLATED FROM SKIN INFECTIONS IN 1994, TO 19 ANTIMICROBIAL AGENTS

The most common pathogen causing skin infections is Staphylococcus aur eus and the incidence of multiply resistant strains of S. aureus has b een increasing. The in vitro susceptibility of 130 isolates of S. aure us to 19 antimicrobial agents: ampicillin (ABPC), methicillin, cefaclo r, cefpodoxime proxetil, gentamicin, erythromycin, clindamycin, minocy cline, vancomycin, fusidic acid, norfloxacin, ofloxacin, enoxacin, cip rofloxacin, lomefloxacin, tosufloxacin, sparfloxacin, nadifloxacin and grepafloxacin, was evaluated by agar dilution tests. The S, aureus is olates were isolated from 130 patients with skin infections in 1994. T he proportion of methicillin-resistant S. aureus isolates among the st rains isolated was 19.2%. The concentration needed to inhibit 50% of t he isolates was 3.13 mg/ml or less for all of the drugs, but the conce ntration needed to inhibit 90% of isolates was over 12.5 mu g/ml, exce pt in the cases of minocycline, vancomycin, fusidic acid, tosufloxacin and nadifloxacin. Tosufloxacin and nadifloxacin had the lowest minimu m inhibitory concentrations. None of the S. aureus strains was resista nt to nadifloxacin.