PREPARATIVE-SCALE SEPARATION OF AMINO-ACIDS BY USING THERMAL ION-EXCHANGE PARAMETRIC PUMPING

Separation of amino acids by thermal parametric pumping is experimenta lly and theoretically investigated. A multicomponent, non-linear model that takes into account the dissociation reaction in liquid phase is used to predict the separation and to investigate the effect of the re sin type on the performance of parametric pumping. Experiments have be en done with different mixtures of glutamic acid, leucine, phenylalani ne, proline, serine and valine. The experimental results demonstrate t he capability of thermal parametric pumping of separating amino acids from aqueous mixtures. The simulations give the correct general behavi our of the experimental results and help to select the resin that is m ore suitable for the separation. Copyright (C) 1997 Elsevier Science L td.