INHIBITION OF CELL-ADHESION BY ANTIADHESIVE MOLECULES

The importance of inhibitory (as well as stimulatory) signals for cell adhesion and/or migration is most readily recognizable during develop ment of the nervous system, where pathfinding and the avoidance of ina ppropriate tracks by axons in the periphery, and the development of or ganized layers and establishment of boundaries in the central nervous system are crucial events. Therefore, most of the recent progress conc erning the identification of novel important extracellular molecules i nvolved in repulsive and inhibitory interactions has been made by neur obiologists.