PHOSPHONIC ACID ANALOG OF FORFENICINE - SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DEGRADATION BY PSEUDOMONAS-FLUORESCENS

Authors
CZERWONKA A LEJCZAK B BODUSZEK B KAFARSKI P
Citation
A. Czerwonka et al., PHOSPHONIC ACID ANALOG OF FORFENICINE - SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DEGRADATION BY PSEUDOMONAS-FLUORESCENS, Amino acids, 12(1), 1997, pp. 101-106
Citations number
10
Categorie Soggetti
Biology
Journal title
Amino acids → ACNP
ISSN journal
09394451
Volume
12
Issue
1
Year of publication
1997
Pages
101 - 106
Database
ISI
SICI code
0939-4451(1997)12:1<101:PAAOF->2.0.ZU;2-K
Abstract
Phosphonic acid analogue of forfenicine, amino (p-formylbenzyl)-phosph onic acid, was synthesized and evaluated as antibacterial agent. As in dicated by disc diffusion test this compound was found to inhibit sign ificantly the growth of Bacillus subtilis and Staphylococcus aureus an d moderately the growth of Escherichia coli. Resistance of Pseudomonas fluorescens to the action of the aminophosphonate may result from the ability of the strain to degrade this compound.