FLOW-INJECTION EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF BROMHEXINE WITH ORANGE-IV

Authors
PEREZRUIZ T MARTINEZLOZANO C SANZ A MONDEJAR S
Citation
T. Perezruiz et al., FLOW-INJECTION EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF BROMHEXINE WITH ORANGE-IV, Journal of pharmaceutical and biomedical analysis, 13(9), 1995, pp. 1101-1106
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
13
Issue
9
Year of publication
1995
Pages
1101 - 1106
Database
ISI
SICI code
0731-7085(1995)13:9<1101:FEDOB>2.0.ZU;2-G
Abstract
An automatic flow-injection photometric method for the determination o f bromhexine is proposed. The drug was determined by formation of an i on-pair with orange IV, extraction into 1,2-dichloroethane and measure ment of the absorbance at 412 nm of the organic phase. A linear calibr ation graph was obtained at concentrations of 5 x 10(-6) - 1.6 x 10(-4 ) M of bromhexine. Up to 40 samples h(-1) can be processed with an RSD of 0.32-0.88%. The method was applied to the determination of bromhex ine in blood serum and a pharmaceutical preparation.