FLOW-INJECTION SPECTROFLUOROMETRIC DETERMINATION OF FLUFENAMIC AND MEFENAMIC-ACID IN PHARMACEUTICALS

Two sensitive and rapid flow-injection (FI) spectrofluorimetric method s are proposed for the determination of flufenamic acid (FF) and mefen amic acid (MF), based on the formation of complexes of these compounds with Al(III) in an ethanolic medium. The calibration graphs resulting from the measurements of the fluorescence at lambda(exc) = 351 nm and lambda(em) = 440 nm, and lambda(exc) = 355 nm and lambda(em) = 454 nm for the complexes with FF and MF, respectively, are linear over the r ange 0.030-1.20 mu g ml(-1) for FF and 0.30-16.1 mu g ml(-1) for MF. T he methods have been applied to the determination of these drugs in ph armaceutical preparations.