POLAROGRAPHIC-DETERMINATION OF PRENALTEROL HYDROCHLORIDE THROUGH TREATMENT WITH NITROUS-ACID

A simple and sensitive polarographic method is described for the deter mination of prenalterol hydrochloride through treatment with nitrous a cid. The different experimental parameters affecting the derivatizatio n process, as well as the polarographic analysis were studied. The der ivatization product was found to be reducible at the dropping mercury electrode over the whole pH range in Britton-Robinson buffers. At pi 5 , a well defined diffusion-controlled cathodic wave was produced. The limiting current vs. the concentration plot was linear over the range 0.015-0.15 mM in the direct current mode, with a minimum detectability of 0.8 mu M. The proposed method was applied successfully to the dete rmination of prenalterol hydrochloride either in the pure form or in i ts dosage forms.