STUDY OF THE STABILITY OF TYLOSIN-A IN AQUEOUS-SOLUTIONS

The decomposition of the 16-membered ring macrolide antibiotic tylosin A in aqueous buffers has been investigated in the pH range 2-13, by m eans of a liquid chromatographic assay with ultraviolet detection at 2 80 Mn. In acidic medium, tylosin A is converted into tylosin B, while in neutral and alkaline medium, tylosin A aldol is formed together wit h a number of polar decomposition products of unknown identity. The de composition kinetics have been studied as a function of the type and c oncentration of the buffer, ionic strength, pH and temperature.