DETERMINATION OF 3-DIMENSIONAL LOW-RESOLUTION VIRAL STRUCTURE FROM SOLUTION X-RAY-SCATTERING DATA

The capsid is modeled as a region of constant electron density located between inner and outer envelopes that exhibit icosahedral symmetry. For computational purposes the envelopes are represented as truncated sums of weighted icosahedral harmonics. Methods are described for esti mating the weights from x-ray solution scattering patterns based on no nlinear least squares, and two examples of the procedure, for viruses with known atomic-resolution structures, are given.