THE HUMAN SOX11 GENE - CLONING, CHROMOSOMAL ASSIGNMENT AND TISSUE EXPRESSION

The mammalian testis determining gene SRY contains an HMG box-related DNA binding motif. By analogy a family of genes related to SRY in the HMG domain have been called SOX (SRY box-related genes). We have clone d and characterized the human SOX11 gene using the partial cloning of both human and mouse SOX11 genes and mapped it to chromosome 2p25. The SOX11 sequence is strongly conserved with the chicken homologue and i s related to SOX4. It contains several putative transcriptional either activator or repressor domains. SOX11 expression pattern is consisten t with the hypothesis that this gene is important in the developing ne rvous system. (C) 1995 Academic Press, Inc.