SERUM ENZYME CHANGES AND THEIR INTERCORRELATIONS DURING A 20-DAY LONGROAD RACE

The study examined the serum enzyme changes of CK, CK-MB, LDH, HBDH, G OT, GPT, AP, GLDH, amylase, CHE, and gamma-GT, measured before and dur ing a 20-day long road race. The daily mileage was about 33 miles. The subjects were 55 finishers (42 males and 13 females; average age 43.1 years). Time series data of all runners indicated maximum average val ues of CK (1173 U/l) and CK-MB (37 U/l) as GOT (60 U/l) on day 3, then continuously falling to 405, 19 and 35 U/l on the last day. LDH paral leling HBDH reached their maxima on day 11 with 449 and 266 U/l. GPT, GLDH and gamma-GT increased to values of 24, 5 and 23 U/l on day 6 wit hout surpassing the reference value border significantly. There was no significant influence of sex or age, but then were high significant c orrelations between CK-MB, CK and GOT as HBDH, CK, GOT and GPT since d ay 3. demonstrating the muscle as main source for the parallel enzyme elevations, supporting the concept of altered membrane permeability in fatigued muscle associated with leakage of different enzymes into blo od. There were no significant correlations between running speed, age, body weight, lean body mass and the enzyme maxima.