MASSIVE SPLENOMEGALY RESPONSIVE TO PROGUANIL AND WITH FEATURES OF HAIRY-CELL LEUKEMIA

Authors
YERMIYAHU T MAISLOS M SHNEIDER A BENMEIR D LOWENTHAL MN
Citation
T. Yermiyahu et al., MASSIVE SPLENOMEGALY RESPONSIVE TO PROGUANIL AND WITH FEATURES OF HAIRY-CELL LEUKEMIA, Transactions of the Royal Society of Tropical Medicine and Hygiene, 89(2), 1995, pp. 194-196
Citations number
22
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
89
Issue
2
Year of publication
1995
Pages
194 - 196
Database
ISI
SICI code
0035-9203(1995)89:2<194:MSRTPA>2.0.ZU;2-S
Abstract
A recent Ethiopian immigrant to Israel presented with pneumococcal sep sis, massive splenomegaly and lymphadenopathy. Investigations revealed many features of both hairy cell leukaemia (HCL) and hyperreactive ma larious splenomegaly (HMS). Proguanil therapy for HMS was followed by rapid, marked decrease in spleen size, disappearance of the tartrate-r esistant acid phosphatase-positive cells characteristic of HCL, and in creasing eosinophilia, but unchanged lymphadenopathy.