SKIN CHANGES IN ACROMEGALY - 4 CASES

Introduction : Some skin changes in acromegaly belong to the classical dysmorphic syndrome. Furthermore, other minor skin changes can be ass ociated. Observations: We report 3 patients consulting in the departme nt of Dermatology for various skin changes that have lead to the diagn osis of acromegaly. However these patients have also typical dysmorphi c syndrome that they have failed to recognize. The fourth patient asso ciated a cutaneous mastocytosis and acromegaly, as reported only once in literature. The evolution of the minor skin changes was parallel wi th the endocrinopathy. Moreover in one case, they have preceded the re currence of the acromegaly. Comments : Our observations demonstrate th e importance of the minor skin changes that lead the patient to consul t more than the dysmorphic syndrome. Moreover these changes that depen d of growth hormone and other associated growth factors can be evoluti ve signs for endocrinopathy.