Introduction : Some skin changes in acromegaly belong to the classical
dysmorphic syndrome. Furthermore, other minor skin changes can be ass
ociated. Observations: We report 3 patients consulting in the departme
nt of Dermatology for various skin changes that have lead to the diagn
osis of acromegaly. However these patients have also typical dysmorphi
c syndrome that they have failed to recognize. The fourth patient asso
ciated a cutaneous mastocytosis and acromegaly, as reported only once
in literature. The evolution of the minor skin changes was parallel wi
th the endocrinopathy. Moreover in one case, they have preceded the re
currence of the acromegaly. Comments : Our observations demonstrate th
e importance of the minor skin changes that lead the patient to consul
t more than the dysmorphic syndrome. Moreover these changes that depen
d of growth hormone and other associated growth factors can be evoluti
ve signs for endocrinopathy.