RELATIONSHIP BETWEEN DUODENAL CALCIUM-UPTAKE AND CA2-MG2+-ATPASE ACTIVITY()

Citation
N. Claassen et al., RELATIONSHIP BETWEEN DUODENAL CALCIUM-UPTAKE AND CA2-MG2+-ATPASE ACTIVITY(), Medical science research, 24(12), 1996, pp. 809-811
Citations number
17
Categorie Soggetti
Medicine, Research & Experimental
Journal title
ISSN journal
02698951
Volume
24
Issue
12
Year of publication
1996
Pages
809 - 811
Database
ISI
SICI code
0269-8951(1996)24:12<809:RBDCAC>2.0.ZU;2-G
Abstract
Intestinal calcium uptake follows both a saturable and a non-saturable uptake route. The saturable route is energy-dependent. Ca2+-Mg2+-ATPa se is mainly responsible for extrusion of calcium from the intestinal enterocyte. Saturable intestinal calcium uptake declines significantly in the rat from 42 days of age until 84 days of age. Similar changes in Ca2+-Mg2+-ATPase activity have not yet been reported. Male Sprague Dawley rats (n=32) were used and the total duodenal calcium uptake and Ca2+-Mg2+-ATPase activity were measured at 28 (n=8), 35 (n=8), 42 (n= 8) and 84 (n=8) +/- 2 days respectively. There was a close relationshi p between total duodenal calcium uptake and Ca2+-Mg2+-ATPase activity during the period 28 to 84 days of age. We conclude that Ca2+-Mg2+-ATP ase activity may also act as a rate-limiting step in intestinal calciu m uptake.