INVERSE CORRELATION OF MALONDIALDEHYDE (MDA) AND ANTI-CU2-DENSITY-LIPOPROTEIN (LDL) IMMUNOGLOBULIN-G (IGG) ANTIBODIES IN TRANSPLANTATION PATIENTS( OXIDIZED LOW)

Malonic dialdehyde (MDA) is one of the major aldehydes synthesised dur ing lipid peroxidation (LPO). LPO occurs in ischaemic situations, such as surgical revascularisation, myocardial infarction, lysis and trans plantation. In the latter, there is still a demand for predictive para meters for rejection and/or infection. Therefore, we measured standard parameters for transplantation monitoring, including neopterin and el astase, together with MDA levels and titres of antibodies binding to C u2+-oxidised LDL (oLAb) to ascertain whether these parameters would gi ve additional information on the outcome of transplantation. There was a positive correlation between MDA and neopterin in the liver transpl antation patients, including one patient with fatal outcome (r=0.76, p <0.001). There were further inverse correlations between oLAb and MDA in liver (r=0.61, p<0.001) and heart transplantations (r=0.54, p<0.05) . We conclude that MDA is a useful parameter for determining prognosis in transplantation patients. Therefore, MDA and oLAb measurements may be additional parameters for predicting the outcome of allograft tran splantation patients.