HYPERPIGMENTATION DUE TO CALCIPOTRIOL (MC-903) PLUS HELIOTHERAPY IN PSORIATIC PATIENTS - 3 CASE-REPORTS

Calcipotriol is a synthetic analogue of vitamin D, used in the treatme nt of psoriasis. Until now no specific side-effects have been describe d after combined therapy with calcipotriol and UV. We describe 3 patie nts, who in the summer of 1993, after a combined treatment of calcipot riol and heliotherapy, developed hyperpigmentation in the site where t he ointment had been applied. Hyperpigmentation healed spontaneously i n less than 7 months. To the best of our knowledge there are no other reports of this side-effect due to calcipotriol. In our opinion the fa ct that the 3 patients presented the hyperpigmentation only on the tre ated lesions and that, in the past, they had not presented similar les ions after exposure to sunlight confirms the relationship between the hyperpigmentation and the combined treatment used.