NALTREXONE USE IN THE TREATMENT OF ANOREXIA-NERVOSA AND BULIMIA-NERVOSA

Our auto-addiction model suggests that opiate blockade may be therapeu tically useful in anorexia nervosa and bulimia nervosa, Naltrexone was administered to out-patient subjects in double-blind clinical trials with randomized cross-over designs, Reduction in binge-purge symptomat ology was evident in the naltrexone period over placebo for 18 out of 19 subjects with either bulimia or anorexia nervosa of the bulimic sub type, in every Ease, the decoding of drug or placebo double blinding c onfirmed the assessments of both the investigator and the subjects, ba sed on the blind analysis of the data and on their therapeutic respons e, respectively. Statistical analysis done on the total population and two diagnostic subgroups found highly significant differences.