L. Kanter et al., UTILITY OF A PROLIFERATION MARKER IN DISTINGUISHING BETWEEN BENIGN NEVOCELLULAR NEVI AND NEVOCELLULAR NEVUS-LIKE LESIONS WITH MALIGNANT PROPERTIES, Melanoma research, 5(5), 1995, pp. 345-350
In the present study we have investigated the utility of the prolifera
tion marker MIB1 in distinguishing between benign naevocellular naevi
and naevocellular naevus-like lesions with malignant potential, Percen
tages of MIB1 immunoreactivity in the intradermal portion of the lesio
ns were determined. In benign congenital and acquired naevi, as well a
s in dysplastic naevi, there was no or only a slight intradermal melan
ocytic proliferation (0-2%), whereas vertical growth phase melanomas e
xhibited a substantial proliferative activity (11-48%). In five cases
of naevus-like lesions, which had all relapsed as unmistakable maligna
nt melanomas (locally or metastatically) after primary surgery, there
was also clear proliferative activity (9-67%). Our findings suggest th
at MIB1 may be a useful tool in the routine histopathological examinat
ion of problematic naevocellular lesions.