Transvaginal ultrasonography and color flow imaging, performed to inve
stigate whether there is any diagnostic advantage, were assessed over
a 3 year period in 217 patients with adnexal masses prior to explorati
ve laparotomy. Gray scale sonography and color Doppler flow were perfo
rmed 1 day prior to surgery. Benign tumors were found in 165 patients
and flow was detectable in 82 (49.7%); 14 patients had tumors of low m
alignant potential, 12 (85.7%) of whom showed detectable flow, and 38
had malignant tumors, in 25 (65.8%) of whom flow was detectable. Blood
flow velocity was evaluated by the calculation of the resistance inde
x prior to surgery. Mean resistive index was 0.39 +/- 0.05 for maligna
nt tumors, compared with 0.49 +/- 0.06 and 0.55 +/- 0.07 for the low m
alignant potential and benign tumors, respectively. These differences
were statistically significant (P < 0.01). When a resistive index of 0
.47 was considered the cut-off value, the sensitivity was 88% and the
specificity was calculated to be 85% (using color Doppler flow as the
only diagnostic method). With our large cohort of patients, we demonst
rated the contribution of color Doppler flow examination in differenti
ating benign from malignant ovarian tumors prior to surgery.