EXPERIMENTAL AND THEORETICAL-ANALYSIS OF THE INTERACTION BETWEEN CYTOCHROME-C AND CYTOCHROME B(5)

Experimental and theoretical investigation of the interaction of cytoc hrome c and cytochrome b(5) performed over nearly twenty years has pro duced considerable insight into the manner in which these proteins rec ognize and bind to each other. The results of these studies and the ex perimental and theoretical strategies that have been developed to achi eve these results have significant implications for understanding the behavior of similar complexes formed by more complex and less-well cha racterized electron transfer proteins. The current review provides a c omprehensive summary and critical evaluation of the literature on whic h the current status of our understanding of the interaction of cytoch rome c and cytochrome b(5) is based. The general issues related to the study of electron transfer complexes of this type are discussed and s ome new directions for future investigation of such systems are consid ered.