Gf. Wiegertjes et al., IMMUNOGENETICS OF DISEASE RESISTANCE IN FISH - A COMPARATIVE APPROACH, Developmental and comparative immunology, 20(6), 1996, pp. 365-381
The study of the genetic regulation of infectious disease resistance d
epends on the availability of inbred lines or selection lines of the s
pecies under investigation, The small numbers of such lines of fish ha
s limited the strategy in teleosts to studies of associations between
disease and immune/health traits, Attempts to correlate genetic differ
ences in immune responsiveness with survival after experimental challe
nge with pathogenic bacteria have failed to define immune parameters t
hat can substantially aid selection for genetic resistance to infectio
us diseases, Advantages and disadvantages of selection strategies as i
llustrated by mouse and chicken models are discussed, In this study we
summarize the present situation in fish as well as our attempts to de
velop gynogenetic lines of carp for immunogenetic research. Copyright
(C) 1996 Elsevier Science Ltd.