IMMUNOGENETICS OF DISEASE RESISTANCE IN FISH - A COMPARATIVE APPROACH

The study of the genetic regulation of infectious disease resistance d epends on the availability of inbred lines or selection lines of the s pecies under investigation, The small numbers of such lines of fish ha s limited the strategy in teleosts to studies of associations between disease and immune/health traits, Attempts to correlate genetic differ ences in immune responsiveness with survival after experimental challe nge with pathogenic bacteria have failed to define immune parameters t hat can substantially aid selection for genetic resistance to infectio us diseases, Advantages and disadvantages of selection strategies as i llustrated by mouse and chicken models are discussed, In this study we summarize the present situation in fish as well as our attempts to de velop gynogenetic lines of carp for immunogenetic research. Copyright (C) 1996 Elsevier Science Ltd.