A CONVENIENT ONE-POT PREPARATION OF DISUBSTITUTED PHOSPHINIC ACIDS DERIVED FROM SIMPLE AMINO-ACIDS AND PROLINE

Authors
BORLOO M JIAO XY WOJTOWICZ H RAJAN P VERBRUGGEN C AUGUSTYNS K HAEMERS A
Citation
M. Borloo et al., A CONVENIENT ONE-POT PREPARATION OF DISUBSTITUTED PHOSPHINIC ACIDS DERIVED FROM SIMPLE AMINO-ACIDS AND PROLINE, Synthesis, (9), 1995, pp. 1074
Citations number
42
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
9
Year of publication
1995
Database
ISI
SICI code
0039-7881(1995):9<1074:ACOPOD>2.0.ZU;2-T
Abstract
A facile method for the preparation of both 2-pyrrolidinyl-substituted phosphinic acids and 1-aminoalkylphosphinic acids is described. React ion of l-pyrroline trimer or N-tritylalkanamine with bis(trimethylsily l)phosphonite, followed by silylation with N,O-bis(trimethylsilyl)acet amide gives an intermediate which is used in a Michael addition reacti on or an Arbuzov reaction.