IN-VIVO EFFECTS OF SUPERANTIGENS

Superantigens are potent immunostimulatory molecules that activate bot h T cells and antigen presenting cells. The consequences of superantig en exposure range from induction of T cell proliferation, massive cyto kine release and systemic shock to immunosuppression and tolerance. Su perantigens have been directly implicated in a number of human conditi ons including food poisoning and toxic shock. In addition, there is ev idence to suggest that superantigens are involved in the initiation of autoimmunity, and the immune dysfunction associated with HIV infectio n. Because of their possible role in human disease, and their potentia l use in immune therapy, it is important that we more completely under stand the in vivo effects of superantigens.