STEREOCHEMISTRY OF ASYMMETRIC CYCLIZATIONS BY PALLADIUM-CATALYZED INTRAMOLECULAR ASYMMETRIC ALLYLATIONS OF CHIRAL ENAMINES, IMINES, AND HYDRAZONES BEARING PHOSPHINE GROUPS

Chiral enamines, imines, and hydrazones bearing phosphine groups at th e chiral centers and allylic parts at the appropriate positions underw ent intramolecular asymmetric carbon-carbon bond formations in the pal ladium-catalyzed reactions to give optically active cyclized products with rather high enantiomeric excess. The mechanism for the asymmetric induction is rationalized on the basis of the stereochemical outcome observed.