ACTIVITY OF CI-960 ALONE AND IN COMBINATION WITH AMOXICILLIN AGAINST LISTERIA-MONOCYTOGENES, AND COMPARISON WITH OTHER QUINOLONES

Authors
BOISIVON A DHOYEN N CARBON C
Citation
A. Boisivon et al., ACTIVITY OF CI-960 ALONE AND IN COMBINATION WITH AMOXICILLIN AGAINST LISTERIA-MONOCYTOGENES, AND COMPARISON WITH OTHER QUINOLONES, Journal of antimicrobial chemotherapy, 36(3), 1995, pp. 527-530
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
36
Issue
3
Year of publication
1995
Pages
527 - 530
Database
ISI
SICI code
0305-7453(1995)36:3<527:AOCAAI>2.0.ZU;2-I
Abstract
In-vitro activity of CI-960 against seven strains of Listeria monocyto genes was compared to that of other fluoroquinolones. MICs/MBCs were: ciprofloxacin and sparfloxacin: 0.5-2/1-4 mg/L; PD 131628: 0.125-0.5/0 .25-2 mg/L; CI-960: 0.06-0.25/0.25-0.5 mg/L. At 4 h, CI-960 (4 x MIG) reduced the inoculum (log(10) cfu) by 2.8 +/- 0.61 compared with 1.78 +/- 0.48 for ciprofloxacin, 1.5 +/- 0.46 for sparfloxacin, and 1.35 +/ - 0.47 for PD 131628 (P < 0.05). At 24 h, the bactericidal effects wer e similar (-4 log(10) cfu). The amoxycillin/CI-960 (8 x MIC) combinati on was bactericidal, without emergence of resistant mutants.