EFFICACY OF QUINOLONES IN PREVENTING STAPHYLOCOCCUS AUREUS-INDUCED ABSCESS IN MICE

Authors
COHEN MA GAGE JW HUBAND MD MESERVEY MA VANDERROEST SR YODER SL
Citation
Ma. Cohen et al., EFFICACY OF QUINOLONES IN PREVENTING STAPHYLOCOCCUS AUREUS-INDUCED ABSCESS IN MICE, Journal of antimicrobial chemotherapy, 36(3), 1995, pp. 551-555
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
36
Issue
3
Year of publication
1995
Pages
551 - 555
Database
ISI
SICI code
0305-7453(1995)36:3<551:EOQIPS>2.0.ZU;2-2
Abstract
The new fluoroquinolones clinafloxacin, CI-990 (PD 131112/PD 131628), sparfloxacin, and PD 138312 were bactericidal against Staphylococcus a ureus with MICs greater than or equal to 4-fold lower than ciprofloxac in values. In a murine subcutaneous abscess model (subcutaneous/oral d osing) the new drugs displayed protective activities against five stra ins which were generally higher (up to 19-fold) than ciprofloxacin val ues.